• br Summary The presented results of the analysis of

  2021-09-27

  

  Summary The presented results of the analysis of the unfolding of G-quadruplex and i-motif, which may appear within the telomeric DNA region, led to several important conclusions. Namely, determination of the work necessary to unfold of these structures, in biased molecular dynamics involving ste

• UO126 Interestingly transgenic mice that constitutively expr

  2021-09-27

  

  Interestingly, transgenic mice that constitutively express active FXR in the intestine (iVP16FXR) are protected from chemically-induced and genetically-induced cholestasis. This protective effect is attributed to the induction of intestinal FGF15 and repression of hepatic Cyp7a1 expression, downregu

• The objective of this study is

  2021-09-27

  

  The objective of this study is to design and synthesize drug-like molecules with agonistic activity on both receptors; PPARγ and FFAR1. These agents would act as insulin sensitizers and insulin secretagogues through their action on PPARγ and FFAR1, respectively. The design of drugs with dual mode of

• Previously we have isolated liver FBPase

  2021-09-27

  

  Previously we have isolated liver FBPase from Pelophylax esculentus (former Rana esculenta, Frost et al., 2006) and characterized its kinetic properties (Dziewulska-Szwajkowska and Dzugaj, 1999) on the contrary the muscle FBPase has never been fully characterized. The primary aim of the present pape

• The lower number of samples tested for the

  2021-09-27

  

  The lower number of samples tested for the comparison between cobas 4800 HIV-1 and RealTime HIV-1, especially at or below 50 copies/mL (Table 6), could limit our ability to discern a difference in the ability of the various assays to identify patients with virological failure. However, the 95% CI ar

• 821 Introduction Histamine Imidazolyl ethylamine is an impor

  2021-09-27

  

  Introduction Histamine [2-(4-Imidazolyl)-ethylamine] is an important mediator of many physiological and pathological processes including inflammation, gastric 821 secretion, neuromodulation, regulation of immune function, cell proliferation and differentiation, among others. Histamine exerts its b

• The concentration of rapamycin that gave half maximal

  2021-09-27

  

  The concentration of rapamycin that gave half-maximal induction of the expression of HO-1 and Prx-1 mRNA in normal hepatocytes was 0.05 μM, with maximal induction at about 0.1 μM rapamycin. While, at rapamycin concentrations higher than 0.1 μM, the degree of enzyme induction decreased, elevated expr

• br Soluble guanylyl cyclase nitric oxide and nitric oxide

  2021-09-27

  

  Soluble guanylyl cyclase, nitric oxide and nitric oxide synthase The primary and best-studied endogenous activator of soluble guanylyl cyclase (sGC) is nitric oxide (NO), which was originally describe as endothelium-derived relaxing factor for its potent ability to relax blood vessels in response

• Annexin A ANXA a member

  2021-09-27

  

  Annexin A7 (ANXA7), a member of annexin superfamily, is a Ca2+- and phospholipid-binding protein and possesses GTPase activity [5,6]. The ANXA7 gene is located on human chromosome 10q21, where multiple potential tumor suppressor genes exist. Homozygous ANXA7 (−/−) knockout mice showed a lethal pheno

• br Material and methods br

  2021-09-27

  

  Material and methods Results and discussion Unlike many fruits such as bananas and tomatoes, known as climacteric fruits, in which ripening is regulated by a burst of ABT biosynthesis and an increase in respiration, pepper fruits, which do not follow this pattern, are called non-climacteric [

• br Introduction Adipose tissue AT in addition to

  2021-09-27

  

  Introduction Adipose tissue (AT), in addition to its function as Flavin adenine dinucleotide storage, is an important endocrine organ and it secretes adipokines (Ahima, 2006). Adipose tissue is related to different physiological processes such as energy metabolism, insulin sensitivity, and inflam

• The DNA cleavage activity assay in the present study also

  2021-09-27

  

  The DNA cleavage activity assay in the present study also demonstrated the DNA glycosylase activities of SMUG1, NEIL1, TDG, and NTHL1 for 5OHU paired with A. While our findings on the activities of SMUG1 and NEIL1 were consistent with the results reported from previous studies [25], [50], the activi

• br Conclusions The whole mRNA sequence of

  2021-09-27

  

  Conclusions The whole mRNA sequence of equine HRG was identified. Consequently, we successfully generated recombinant equine HRG. By the Western blot procedure, blood HRG in horses was detected. Acknowledgments Introduction Alzheimer's disease (AD) is a chronic neurological disorder with c

• There were significant differences in mRNA expression

  2021-09-27

  

  There were significant differences in mRNA expression levels observed for 7 out of 15 analyzed genes. This observation suggests, that selection of a reference/control group may influence interpretation of gene expression studies performed in liver pathologies. This study directly evidenced that anal

• Na K ATPase adenosine triphosphate ATP and

  2021-09-27

  

  Na+/K+-ATPase, Cy3.5 maleimide and astrocytic glutamate transporters act together to maintain sodium and potassium gradients and the proper activities of EAAT1 and EAAT2 (Rose et al., 2009; Sheean et al., 2013); nevertheless, in present study, Na+/K+-ATPase activity was shown to be increased as from

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